Differential regulation of muscle acetylcholine receptor γ‐and ϵ‐subunit mRNAs

FEBS Letters

Sakmann, Bert¹  Witzemann, Veit³  Nishikawa, Yoshiki²  Numa, Shosaku²  Barg, Brigitte³ 

[1] Zellphysiologie, Max-Planck-Institut für biophysikalische Chemie, D-3400 Göttingen, FRG;Departments of Medical Chemistry and Molecular Genetics, Kyoto University Faculty of Medicine, Kyoto 606, Japan;Abteilung Neurochemie, Max-Planck-Institut für biophysikalische Chemie, D-3400 Göttingen, FRG

关键词: Acetylcholine receptor;    Denervation;    Reinnervation;    RNA blot hybridization analysis;    Patch-clamp analysis;    (Rat diaphragm);    AChR;    acetylcholine receptor;    ACh;    acetylcholine;   

DOI  :  10.1016/0014-5793(87)80518-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The contents of the mRNAs encoding the γ- and ϵ-subunits of the nicotinic acetylcholine receptor as well as the single-channel properties of the receptor have been assessed in innervated, denervated and reinnervated rat muscle. The changes in abundance of the γ- and ϵ-subunit mRNAs correlate with the changes in relative density of two classes of acetylcholine receptor channels. The results support the view that a switch in the relative abundance of the γ- and ϵ-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle.

【 授权许可】

Unknown