Immunocytochemical localization of protein kinase C in resting and activated human neutrophils

FEBS Letters

Kuo, J.F.²  Deli, Eva²  Wilson, Emily¹  Lambeth, J.David¹  Kiss, Zoltan² 

[1] Departments of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA;>Departments of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA

关键词: Protein kinase C;    Neutrophil;    (Human);    FMLP;    N-formyl-methionyl-leucyl-phenylalanine;    TPA;    12-O-tetradecanoylphorbol-13-acetate;    PKC;    protein kinase C;   

DOI  :  10.1016/0014-5793(87)80957-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An immunocytochemical method was used to determine possible changes in the subcellular distribution of protein kinase C (PKC) in human neutrophils in response to opsonized latex beads and zymosan. While in resting cells most of the PKC immunoreactivity was localized in the cytoplasm, a redistribution of PKC to the plasma and phagosomal membranes was observed in cells treated with latex beads or zymosan for 5–20 min, suggesting a participation of PKC in endocytosis.

【 授权许可】

Unknown