Glutathione peroxidase and oxidative hemolysis in trout red blood cells

FEBS Letters

Cincolà, Giulio¹  Falcioni, Giancarlo¹  Brunori, Maurizio² 

[1] >Department of Cell Biology, University of Camerino, Camerino, Italy;Department of Biochemical Sciences, University ‘La Sapienza’, Rome, Italy

关键词: Methemoglobin;    Oxygen radical;    Hemolysis;   

DOI  :  10.1016/0014-5793(87)80955-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Red blood cells from the trout Salmo irideus contain several hemoglobin components that are prone to oxidation with production of oxygen radicals. The rate of hemolysis has been correlated to the extent of methemoglobin formation. A difference in the rate of hemolysis between red blood cells saturated with either CO or O₂ was evident only when diminished glutathione peroxidase activity was observed. These results confirm the important role of this enzyme in providing protection against or repair of oxidative damage to the red cell membrane.

【 授权许可】

Unknown