Co‐evolution of base composition and codon usage in Xenopus laevis and human globin genes with long‐range DNA organization of their genome

FEBS Letters

Scherrer, K.¹  Moreau, J.¹ 

[1] Institut Jacques Monod, 2, Place Jussieu, 75251 Paris Cedex 05, France

关键词: Globin gene;    A+T-rich sequence;    Electron microscopy;    Codon usage;   

DOI  :  10.1016/0014-5793(87)80342-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Eucaryotic DNA is punctuated by many A+T-rich segments that we named A+T-rich linkers. Two types of these A+T-rich linkers can be distinguished: (i) isolated A+T-rich linkers, and (ii) A+T-rich linkers crowded in clusters. We have analysed the distribution of A+T-rich linker across the α- and β-globin gene domain in Xenopus laevis and human genomes using isodenaturation and electron microscopy. Comparison of our data with those previously obtained for the avian globin genes leads us to conclude that genes can be harboured indifferently in either domain. A correlation is established between the presence of A+T-rich linker inside introns and flanking regions and the A+T content of the coding sequence. For the coding sequence, a high A+T content is strongly correlated with high A+T content in the codon's third position and weakly in the first position.

【 授权许可】

Unknown