Influence of prostaglandins on the lipid transfer between human high density and low density lipoproteins

FEBS Letters

Bergelson, L.D.¹  Korobkova, E.N.¹  Muzya, G.I.¹  Golovanova, N.K.¹ 

[1] Institute of Experimental Cardiology, Cardiology Research Center, USSR Academy of Medical Sciences, Moscow, USSR

关键词: Prostaglandin;    Lipid transfer;    Cholesterol esterification;    LDL;    HDL;    (Human);    PG;    prostaglandins;    DPPC;    dipalmitoylphosphatidylcholine;    HDL;    high density lipoproteins;    LDL;    low density lipoproteins;    LEP;    lipid exchange protein;    LDP;    lipoprotein-depleted plasma;    LCAT;    lecithin:cholesterol acyltransferase (EC 2.3.1.43);   

DOI  :  10.1016/0014-5793(87)80849-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Prostaglandin (PG) E₁ was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL₃) to low density lipoproteins (LDL). The enhancement effect of PGE₁, on the interlipoprotein lipid transfer was seen at low PG concentrations under conditions of spontaneous exchange as well as in the presence of lipoprotein-depleted plasma, or partly purified plasma lipid exchange protein. PGE₂ and PGF_2α showed no significant influence on the interlipoprotein lipid transfer. Evidence is presented suggesting that the PGE₁-induced stimulation of interlipoprotein lipid exchange results in enhancement of LCAT-catalyzed cholesterol esterification in plasma. It is proposed that the effect of PGE₁ is due to the previously described PGE₁-induced reorganization of the HDL surface [(1984) FEBS Lett. 173, 291-293] and that PG-lipoprotein interaction may be a factor regulating cholesterol homeostasis.

【 授权许可】

Unknown