Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase

FEBS Letters

Kinoshita, Jin H.²  Craft, Cheryl¹  Carper, Deborah²  Dietzchold, Bernard³  Wistow, Graeme²  Kador, Peter²  Nishimura, Chihiro²  Shinohara, Toshimichi² 

[1] Dept of Psychiatry, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235, USA;National Eye Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA;Wistar Institute, 36th at Spruce St, Philadelphia, PA 19104 USA

关键词: Aldose reductase;    Aldehyde reductase;    ϱ-Crystallin;    Structural homology;    cDNA sequence;   

DOI  :  10.1016/0014-5793(87)80905-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Aldose reductase (EC 1.1.1.21) has been implicated in a variety of diabetic complications. Here we present the first primary sequence data for the rat lens enzyme, obtained by amino acid and cDNA analysis. We have found structural similarities with another NADPH-dependent oxidoreductase: human liver aldehyde reductase (EC 1.1.1.2). The identity between these two enzymes is 50%. Both enzymes share approx. 40–50% homology with ϱ-crystallin, a major lens protein present only in the frog, Rana pipiens. We propose that aldose reductase, aldehyde reductase and ϱ-crystallin are members of a superfamily of related proteins.

【 授权许可】

Unknown