Neurohypophyseal peptide inhibition of adenylate cyclase activity in fish gills The effect of environmental salinity

FEBS Letters

Guibbolini, Marielle E.¹  Lahlou, Brahim¹ 

[1] Laboratoire de Physiologie Cellulaire et Comparée and CNRS UA 651, Université de Nice, Parc Valrose, 06034 Nice Cedex, France

关键词: Adenylate cyclase;    Neurohypophyseal peptide;    Arginine-vasotocin;    Isotocin;    Salt adaptation;    (Trout gill);   

DOI  :  10.1016/0014-5793(87)80883-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adenylate cyclase activity was measured in plasma membranes prepared from gill epithelium of the rainbow trout (Salmo gairdneri) adapted to a large range of salinity (deionized water to seawater). Fish neurohypophyseal peptides (arginine-vasotocin and isotocin) elicited a dose-dependent inhibition (maximum for 10⁻¹²−10⁻¹⁰ M which corresponds to physiological blood concentrations) of both basal and 10⁻⁹ M glucagon stimulated enzyme activity. While basal activity was inhibited by up to 40% only in high salt media, glucagon-stimulated activity was lowered by 60–100% for the same concentrations, in both freshwater and seawater.

【 授权许可】

Unknown