Properties of B‐ring analogues of colchicine

FEBS Letters

Bhattacharyya, B.¹  Maity, Sankar N.¹ 

[1] Department of Biochemistry, Bose Institute, Calcutta 700054, India

关键词: Colchicine analog;    Tubulin;    Absorption spectrum;   

DOI  :  10.1016/0014-5793(87)81027-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Absorption spectra of colchicine and its analogues are affected by the presence of the B-ring, although it is not part of the chromophore (C-ring). Thus, 2-methoxy-5-(2′,3′4′-trimethoxyphenyl)tropone has absorption maxima at 341 nm, whereas that of desacetamidocolchicine is at 353 nm. A similar red shift in the λ_max of colchicine, desacetamidocolchicine and 2-methoxy-(2′,3′,4′-trimethoxyphenyl)tropone also occurs when they are immobilized in the binding site to tubulin or in pure glycerol. We also observed that the B-ring of colchicine alone or with substituent does not affect the UV-induced rearrangement of colchicine to lumicolchicine. However, in the absence of the B-ring, as in the case of 2-methoxy-5-(2′,3′4′-trimethoxyphenyl)tropone, the rearrangement reaction of the C-ring slows down significantly.

【 授权许可】

Unknown