Regulation of low density lipoprotein metabolism by 26‐hydroxycholesterol in human fibroblasts

FEBS Letters

Bernini, Franco¹  Lorenzo, José L.¹  Allorio, Maria¹  Corsini, Alberto¹  Fumagalli, Remo¹ 

[1] Institute of Pharmacological Sciences, University of Milan, I-20133 Milan, Italy

关键词: 26-Hydroxycholesterol;    Oxysterol;    LDL;    LDL receptor;    (Human fibroblast);   

DOI  :  10.1016/0014-5793(87)81022-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of ¹²⁵I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.

【 授权许可】

Unknown