The amino acid sequence of toxin RpIII from the sea anemone, Radianthus paumotensis

FEBS Letters

Walsh, Kenneth A.²  Metrione, Robert M.²  Schweitz, Hugues¹ 

[1] Centre de Biochitnie du CNRS, Université de Nice, 06034 Nice Cedex, France;Department of Biochemistry, University of Washington, Seattle, WA 98195, USA

关键词: Na+ channel toxin;    Amino acid sequence;    Sequence homology;    (Sea anemone);   

DOI  :  10.1016/0014-5793(87)81018-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The amino acid sequence of the sodium channel toxin Rp_III from the sea anemone Radianthus paumotensis has been determined. The protein is homologous with five analogous toxins from three anemone species and is most similar to a less toxic protein, Rp_II, from the same organism. Twelve residues are conserved in all six toxins, one of which is an arginine residue thought to be essential for toxicity. The others (Cys, Gly, Pro and Trp) tend to be conserved in other sets of homologous proteins to maintain functional folds. Comparisons of the sequences suggest the existence of two separate but related classes of toxins cumon the three species of anemone.

【 授权许可】

Unknown