Contraction‐associated translocation of protein kinase C in rat skeletal muscle

FEBS Letters

Clark, Michael G.¹  Richter, Erik A.²  Rattigan, Stephen¹  Cleland, Perry J.F.¹ 

[1] >Department of Biochemistry, University of Tasmania, Hobart, Australia;August Krogh Institute, University of Copenhagen, Copenhagen, Denmark

关键词: Ca2+ phospholipid-dependent protein kinase;    Exercise;    Muscle contraction;   

DOI  :  10.1016/0014-5793(87)80669-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.

【 授权许可】

Unknown