Locustatachykinin I and II, two novel insect neuropeptides with homology to peptides of the vertebrate tachykinin family

FEBS Letters

Holman, G.Mark²  Schoofs, Liliane¹  Nachman, Ronald J.²  Hayes, Timothy K.³  De Loof, Arnold¹ 

[1] Zoological Institute, Katholieke Universiteit Leuven, Naamsestraat 59, 3000 Leuven, Belgium;Veterinary Toxicology and Entomology Research Laboratory, Agricultural Research Service, US Dept. of Agriculture, F and B Road, College Station, TX 77840 USA;Laboratories for Invertebrate Neuroendocrine Research, Dept. of Entomology, Texas A&M University, College Station, TX 77843, USA

关键词: Tachykinin;    Locusta migratoria;    Substance P;    Insect neuropeptide;    Myotropin;    Muscle contraction;    Homology;    Locustatachykinin;   

DOI  :  10.1016/0014-5793(90)80601-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two myotropic peptides termed locustatachykinin I (Gly-Pro-Ser-Gly-Phe-Tyr-Gly-Val-Arg-NH₂) and locustatachykinin II (Ala-Pro-Leu-Ser-Gly-Phe-Tyr-Gly-Val-Arg-NH₂) were isolated from brain-corpora cardiaca-corpora allata-suboesophageal ganglion extracts of the locust, _{Locusta migratoria}. Both peptides exhibit sequence homologies with the vertebrate tachykinins. Sequence homology is greater with the fish and amphibian tachykinins (up to 45%) than with the mammalian tachykinins. In addition, the intestinal myotropic activity of the locustatachykinins is analogous to that of vertebrate tachykinins. The peptides discovered in this study may just be the first in a whole series of substances from arthropod species to be identified as tachykinin family peptides. Moreover, both chemical and biological similarities of vertebrate and insect tachykinins substantiate the evidence for a long evolutionary history of the tachykinin peptide family.

【 授权许可】

Unknown