Structural features in aminoacyl‐tRNAs required for recognition by elongation factor Tu

FEBS Letters

Faulhammer, Heinz G.¹  Joshi, Rajiv L.¹ 

[1] Institut Jacques Monod, 2 Place Jussieu, 75251 Paris Cedex 05, France

关键词: Protein synthesis;    aminoacyl-tRNA;    Elongation factor Tu;    Ternary complex;   

DOI  :  10.1016/0014-5793(87)80664-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In bacterial polypeptide synthesis aminoacyl-tRNA (aa-tRNA) bound to elongation factor Tu (EF-Tu) and GTP is part of a crucial intermediate ribonucleoprotein complex involved in the decoding of messenger RNA. The conformation and topology as well as the affinity of the macromolecules in this ternary aa-tRNA·EF-Tu·GTP complex are of fundamental importance for the nature of the interaction of the complex with the ribosome. The structural elements of aa-tRNA required for interaction with EF-Tu and GTP and the resulting functional implications are presented here.

【 授权许可】

Unknown