Enhanced prostaglandin E2 and thromboxane B2 release from resident peritoneal macrophages isolated from morphine‐dependent rats

FEBS Letters

Dzoljic, M.R.¹  van Batenburg, M.J.¹  Elliott, G.R.¹ 

[1] Department of Pharmacology, Erasmus University Rotterdam, POB 1738, 3000 DR, Rotterdam, The Netherlands

关键词: Morphine;    Opiate addiction;    [D-Ala2]-Met-enkephalin;    Prostaglandin;    Macrophage;    (Rat);   

DOI  :  10.1016/0014-5793(87)81231-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Resident peritoneal macrophages from morphine-addicted rats (4 days) released more prostaglandin (PG) E₂ and thromboxane (Tx) B₂, but not 6-keto-PGF_1a, than cells from control animals. This effect, which was due to an enhancement of endogenous AA turnover, was not related to any changes in cAMP synthesis or lysososomal enzyme secretion. [D-Ala²]-Met-enkephalin had no effect on eicosanoid release in vitro. Both morphine and PGE₂ have been shown to depress macrophage functions. We suggest that morphine-stimulated macrophage PGE₂ synthesis, and the consequent inhibition of phagocytosis, could contribute to the decreased resistance to infections associated with opiate addiction.

【 授权许可】

Unknown