Metabolism of acetaldehyde in human and baboon renal cortex

FEBS Letters

Baverel, G.¹  Michoudet, C.¹ 

[1] Institut National de la Santé et de la Recherche Médicale (U 80) and Centre National de la Recherche Scientifique (UA 1177), Laboratoire de Physiologie Rénale et Métabolique, Faculté de Médecine Alexis Carrel, 69008 Lyon, France

关键词: Acetaldehyde;    Ethanol;    Acetaldehyde metabolism;    (Human;    Baboon kidney);   

DOI  :  10.1016/0014-5793(87)80767-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Acetaldehyde (1–20 mM) was metabolized at high rates and in a dose-dependent manner in isolated human and baboon kidney-cortex tubules. Acetaldehyde removal was accompanied by a large accumulation of acetate in both human and baboon tubules. By contrast, a large synthesis of ethanol was observed only in baboon tubules. Consistent with the latter finding, ethanol was found to be metabolized at significant rates in baboon but not human tubules. In the tubules from both species, a significant fraction of the acetaldehyde removed was also completely oxidized to CO₂ and H₂O. These results suggest that, in both man and baboon, the kidneys participate in the in vivo metabolism of acetaldehyde; they also suggest that, in contrast with the human kidneys, the baboon kidneys contribute to the detoxication of circulating ethanol.

【 授权许可】

Unknown