Histidine‐rich glycoprotein is evolutionarily related to the cystatin superfamily

FEBS Letters

Odani, Shoji¹  Koide, Takehiko¹ 

[1] Department of Biochemistry, Niigata University School of Medicine, Asahimachi-dori 1, Niigata 951, Japan

关键词: Histidine-rich glycoprotein;    Kininogen;    Cystatin superfamily;    Cysteine proteinase inhibitor;    Evolution;    Sequence homology;   

DOI  :  10.1016/0014-5793(87)80748-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new member of the cystatin superfamily is introduced. Human plasma histidine-rich glycoprotein (HRG) was found to contain 2 cystatin-like sequences in tandem in the N-terminal region. Domain 1 (residues 1–112) was most homologous to domain 1 of the heavy chain of human kininogen and domain 2 (residues 113–225) was most homologous to human cystatin S as well as other cystatins and domain 3 of the heavy chain of kininogen, suggesting that the cystatin domains of HRG may represent a hitherto unknown binary form (or intermediate molecule) composed of 2 cystatin domains, and evolutionarily intermediate between the cystatin and the kininogen families.

【 授权许可】

Unknown