The human preproapolipoprotein C‐II gene

FEBS Letters

Brewer, H.Bryan¹  Law, Simon W.¹  Fojo, Silvia S.¹ 

[1]Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA

关键词: Preproapolipoprotein C-II;    Genomic sequence;    Oligonucleotide probe;    Lipoprotein metabolism;    apo;    apolipoprotein;    VLDL;    very low density lipoproteins;    bp;    base pair;   

DOI  :  10.1016/0014-5793(87)81495-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The complete nucleic acid sequence of human preproapolipoprotein (apo) C-II has been determined from 2 apoC-II clones isolated from 2 different human genomic DNA libraries. The cloned fragments were approx. 14 and 18 kb long, and sequence analysis established that the apoC-II gene consists of 3338 nucleotides containing 3 intervening sequences of 2391, 167, and 298 bases. The first intron is located within the 5'-untranslated region of apoC-II and contains 4 Alu type sequences. The second intron interrupts the codon specifying amino acid —11 of the apoC-II signal peptide. The last intron, which contains a 38 bp sequence which is repeated 6 times, interrupts the codon specifying for amino acid +44 of the mature apolipoprotein.

【 授权许可】

Unknown