Expression of the T4 molecule (AIDS virus receptor) by human brain‐derived cells

FEBS Letters

Stevenson, Mario¹  Volsky, David J.¹  Dewhurst, Stephen¹ 

[1] Molecular Biology Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68105, USA

关键词: Human immunodeficiency virus (HIV);    AIDS;    HIV receptor;    Astrocyte;    T4 antigen;    Glial fibrillary acidic protein;    HIV;    human immunodeficiency virus;    AIDS;    acquired immune deficiency syndrome;    GFAP;    glial fibrillary acidic protein;   

DOI  :  10.1016/0014-5793(87)81478-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Three human cell lines of astrocytic origin were evaluated for expression of a human T-lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT-4 antibody and flow cytometry. Gene transcripts encoding the T4 molecule were detected by a ribonuclease protection assay in surface T4-positive and -negative cells. Our results suggest that astrocytes may serve as targets for HIV infection in the brain.

【 授权许可】

Unknown