Brain spectrin fragments and crosslinks actin filaments

FEBS Letters

Strömqvist, Mats¹ 

[1] Department of Biochemistry, University ofUmea, S-901 87 Umeå, Sweden

关键词: Actin;    Actin polymerization;    Spectrin;    Fodrin;    Cytoskeleton;    (Brain);   

DOI  :  10.1016/0014-5793(87)81472-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of brain spectrin (fodrin) on actin has been studied using viscometry and fluorimetry. Brain spectrin resembles erythrocyte spectrin tetramer in its action on actin. Both proteins crosslink actin filaments giving rise to a large increase in the viscosity but fluorimetry shows that neither affects actin polymerization significantly. In addition, brain spectrin as well as erythrocyte spectrin fragments preformed actin filaments. Actin filaments incubated in the presence of either of the two proteins incorporate actin monomers at a much higher rate showing that more filament ends are generated.

【 授权许可】

Unknown