Effect of spectrin dimer on actin polymerization

FEBS Letters

Backman, Lars¹  Shanbhag, Vithaldas P.¹  Strömqvist, Mats¹ 

[1] Department of Biochemistry, University of Umeå, S-901 87 Umeå, Sweden

关键词: Actin;    Actin polymerization;    Spectrin;    Band 4.1;    Erythrocyte;    Cytoskeleton;   

DOI  :  10.1016/0014-5793(85)80417-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Spectrin dimer is shown to influence the polymerization behaviour of actin. The polymerization of both Mg²⁺- and Ca²⁺-actin is regulated by an enhancement in the rate of nucleation and a fragmentation of preformed actin filaments. In addition, spectrin decreases the critical concentration of Ca²⁺-actin but not that of Mg²⁺-actin. This suggests that the two types of actin may differ in their interaction with spectrin dimer probably due to the different conformations. Band 4.1 elevates the effects of spectrin under non-equilibrium conditions but its contribution is less at steady state.

【 授权许可】

Unknown