Allopurinol and oxypurinol are hydroxyl radical scavengers

FEBS Letters

Grootveld, Martin¹  Moorhouse, P.Christopher¹  Halliwell, Barry¹  Gutteridge, John M.C.²  Quinlan, J.Gregory² 

[1] Department of Biochemistry, King's College, Strand Campus, London WC2R 2LS, England;National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, England

关键词: Ischemia;    Reperfusion damage;    Xanthine oxidase;    Allopurinol;    Oxypurinol;    hydroxyl radical scavenger;   

DOI  :  10.1016/0014-5793(87)81458-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Allopurinol is a scavenger of the highly reactive hydroxyl radical (k ₂ approx. 10⁹ M⁻¹s⁻¹). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol. Oxypurinol is a better hydroxyl radical scavenger than is allopurinol (k ₂ approx. 4 × 10⁹ M⁻¹s⁻¹) and it also reacts with the myeloperoxidase-derived oxidant hypochlorous acid. Hence the protective actions of allopurinol against reperfusion damage after hypoxia need not be entirely due to xanthine oxidase inhibition.

【 授权许可】

Unknown