Stoichiometry of sodium‐ and chloride‐coupled glycine transport in synaptic plasma membrane vesicles derived from rat brain

FEBS Letters

Aragón, M.Carmen¹  Giménez, Cecilio¹  Mayor, Federico¹ 

[1] Departamento de Biología Molecular, Centra de Biologia Molecular, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain

关键词: Stoichiometry;    Glycine transport;    Membrane vesicle;    (Rat brain);   

DOI  :  10.1016/0014-5793(87)81562-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The stoichiometric properties of the glycine transporter were studied in synaptic plasma membrane vesicles from rat brain. The present results, together with previous data from our laboratory, allow us to suggest a Stoichiometry of 2 Na⁺ and 1 Cl⁻ per glycine zwitterion for the translocation cycle catalyzed by the glycine carrier. We propose a kinetic model with an ordered mechanism for the binding/debinding of solutes.

【 授权许可】

Unknown