Pertussis toxin inhibits the angiotensin II and serotonin‐induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta

FEBS Letters

Marmé, Dieter¹  Bruns, Christian¹ 

[1] Institut für Biologie III, University of Freiburg, Schänzlestrasse 1, 7800 Freiburg, FRG

关键词: Angiotensin II;    Serotonin;    intracellular Ca2+;    Pertussis toxin;    (Smooth muscle cell);   

DOI  :  10.1016/0014-5793(87)81552-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Angiotensin II, serotonin and K⁺-depolarization cause an increase in free cytoplasmic Ca²⁺ in cultured smooth muscle cells. The involvement of a guanine nucleotide-binding protein has been investigated by using pertussis toxin. When smooth muscle cells were pretreated with pertussis toxin angiotensin II and serotonin-induced rise of cytosolic Ca²⁺ was found to be significantly reduced whereas the Ca²⁺ influx mediated by K⁺-depolarization remained unchanged. These results suggest the participation of a guanine nucleotide-binding protein in the receptor-mediated rise of intracellular Ca²⁺.

【 授权许可】

Unknown