Ethylene glycol causes acyl chain disordering in liquid‐crystalline, unsaturated phospholipid model membranes, as measured by 2H NMR

FEBS Letters

Nicolay, Klaas²  de Kruijff, Ben²  Smaal, Erik B.¹ 

[1] Department of Biochemistry, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands;Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands

关键词: Ethylene glycol Membrane disordering Dehydration2H NMR Dioleoylphosphatidylcholine Dioleoylphosphatidic acid;    DOPA;    dioleoylphosphatidic acid;    DOPC;    dioleoylphosphatidylcholine;    EG;    ethylene glycol;   

DOI  :  10.1016/0014-5793(86)81079-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

²H NMR has been used to probe the effects of ethylene glycol at the level of the acyl chains in liposomes prepared from dioleoylphosphatidic acid or dioleoylphosphatidylcholine, labeled with ²H at the 11-position of both oleic acid chains. Increasing concentrations of ethylene glycol lead to a proportional and substantial decrease in the quadrupolar splittings, measured from the ²H NMR spectra of both liposomal systems, indicative of acyl chain disordering.

【 授权许可】

Unknown