期刊论文详细信息
FEBS Letters | |
Ethylene glycol causes acyl chain disordering in liquid‐crystalline, unsaturated phospholipid model membranes, as measured by 2H NMR | |
Nicolay, Klaas2  de Kruijff, Ben2  Smaal, Erik B.1  | |
[1] Department of Biochemistry, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands;Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands | |
关键词: Ethylene glycol Membrane disordering Dehydration2H NMR Dioleoylphosphatidylcholine Dioleoylphosphatidic acid; DOPA; dioleoylphosphatidic acid; DOPC; dioleoylphosphatidylcholine; EG; ethylene glycol; | |
DOI : 10.1016/0014-5793(86)81079-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
2H NMR has been used to probe the effects of ethylene glycol at the level of the acyl chains in liposomes prepared from dioleoylphosphatidic acid or dioleoylphosphatidylcholine, labeled with 2H at the 11-position of both oleic acid chains. Increasing concentrations of ethylene glycol lead to a proportional and substantial decrease in the quadrupolar splittings, measured from the 2H NMR spectra of both liposomal systems, indicative of acyl chain disordering.
【 授权许可】
Unknown
【 预 览 】
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