Inactivation of the galactose transport system in Saccharomyces cerevisiae

FEBS Letters

Lagunas, Rosario¹  DeJuan, Carmen¹ 

[1] Instituto de Investigaciones Biomédicas del CSIC, Facultad de Medicina de la UAM, Arzobispo Morcillo 4, 28029 Madrid, Spain

关键词: (Saccharomyces cerevisiae);    Sugar transport;    Galactose;    Transport inactivation;   

DOI  :  10.1016/0014-5793(86)81500-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The galactose transport system of Saccharomyces cerevisiae consists of one component which shows a K _m value of approx. 4 mM in growing cells. A rapid and irreversible inactivation of this transport is detected on impairment of protein synthesis. This inactivation shows the following characteristics: (i) it is due to changes in the K _m and V _max of the transport system; (ii) it follows first-order kinetics; (iii) it is an energy-dependent process and is stimulated by the presence of an exogenous carbon source; (iv) fermentable substrates stimulate inactivation more efficiently than non-fermentable substrates.

【 授权许可】

Unknown