1,25‐Dihydroxyvitamin D3 enhances prostaglandin E2 production by monocytes

FEBS Letters

Rotem, C.²  Novogrodsky, A.³  Liberman, U.A.²  Koren, R.²  Shohami, E.¹  Ravid, A.³ 

[1] Department of Pharmacology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel;The Unit of Metabolic Diseases, Beilinson Medical Center, Petah-TikvaIsrael;Rogoff-Wellcome Medical Research Institute, Beilinson Medical Center, Petah-Tikva, Israel

关键词: 1;    25-Dihydroxy vitamin D3;    Prostaglandin E;    Monocyte;    Lymphocyte activation;    1;    25(OH)2D3;    1;    25-dihydroxyvitamin D3;    PHA;    phytohemagglutinin;    ConA;    concanavalin A;    PGE2;    prostaglandin E2;    PBM;    peripheral blood mononuclear;   

DOI  :  10.1016/0014-5793(86)80876-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Partial removal of monocytes from human peripheral blood mononuclear cells, or the addition of indomethacin. reduced the antiproliferative effect of 1,25(OH)₂D₃ on mitogen-stimulated mononuclear cells. Addition of 1,25(OH)₂D₃ (1nM) to mitogen-stimulated mononuclear cells caused a 2–4-fold increase in prostaglandin E₂ production during the second day of culture. The inhibitory effect of 1,25(OH)₂D₃ on lymphocyte proliferation is greatly augmented up to 7-fold in the presence of prostaglandin E₂. We conclude that monocytes are involved in the inhibitory effect of 1,25(OH)₂D₃ on the mitogenic stimulation of human lymphocytes and that their action is probably mediated by prostaglandins.

【 授权许可】

Unknown