Hormonal regulation of phosphorylase phosphatase activity in rat liver

FEBS Letters

Farkas, Ilona¹  Tóth, Béla¹  Bot, György¹  Gergely, Pál¹ 

[1] Institute of Medical Chemistry, University School of Medicine, Debrecen, Bem tér 18/B, H-4026, Hungary

关键词: Glycogen metabolism;    Hormonal regulation;    Protein phosphatase;   

DOI  :  10.1016/0014-5793(86)80753-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of glucagon and insulin on rat liver phosphorylase phosphatase activity in vivo was investigated. The activity of phosphatase was found to decrease following the administration of glucagon and increase with insulin in a reversible manner. No change was detected in the activity of heat-stable phosphatase inhibitors in the hormone-treated samples. Liver protein kinases (regulatory subunit of cAMP-dependent protein kinase and/or Ca²⁺ -dependent phosphorylase kinase) are suggested to regulate the activity of hepatic phosphorylase phosphatase (type 1 and 2A).

【 授权许可】

Unknown