Occurrence of a novel glycolipid, 'trehalose 2,3,6'‐trimycolate' in a psychrophilic, acid‐fast bacterium, Rhodococcus aurantiacus (Gordona aurantiaca)

FEBS Letters

Imaizun, Sadao²  Kurano, Fusako¹  Kato, Yoshiko¹  Tomiyasu, Ikuko⁴  Kaneda, Kenji²  Yano, Ikuya³  Yoshinaga, Junji¹ 

[1] Osaka Research Institute of Sawai Pharmaceutical Co., Ikue-1, 8014, Asahi-ku, Osaka 535, Japan;Department of Bacteriology, Niigata University School of Medicine, Asahimachi-dori I, Niigata 951 Japan;Department of Bacteriology, Osaka City University Medical School, Asahimachi-1, Abeno-ku, Osaka 545, Japan;Tezukayama Junior College, Gakuen-minami-3, Nara 631, Japan

关键词: Trehalose trimycolate;    Asymmetric ester;    Mycolic acid;    Cord factor;    Acid-fast bacillus;   

DOI  :  10.1016/0014-5793(86)80750-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new type of glycolipid possessing trehalose and mycolic acids has been identified in the lipids of Rhodococcus aurantiacus (Gordona aurantiaca), a psychrophilic acid-fast bacterium. Gas Chromatographic and gas chromatographic-mass spectrometric analysis of hydrolysis products of the most abundant glycolipid class (GM) (containing approx. 50% of the total lipids) showed that the hydrophilic moiety was composed essentially of trehalose, while the hydrophobic moiety contained C_62-74 polyunsaturated mycolic acids only. Permethylation study revealed that the new glycolipid possessed three mycolic acid residues for each trehalose molecule and was identified as trehalose 2,3,6'-trimycolate.

【 授权许可】

Unknown