A proteolipid in cancer cells is the origin of their high‐resolution NMR spectrum

FEBS Letters

Dyne, Marlen¹  Mountford, Carolyn E.¹  Wright, Lesley C.¹  May, George L.¹ 

[1] Ludwig Institute for Cancer Research (Sydney Branch), Blackburn Building, University of Sydney, NSW 2006, Australia

关键词: NMR;    Proteolipid;    (Human serum);    Malignancy;   

DOI  :  10.1016/0014-5793(86)80735-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

High-resolution proton nuclear magnetic resonance studies show that the spectrum of a proteolipid complex, isolated from the serum of patients with malignant diseases, is directly comparable with that obtained from intact cancer cells and solid tumours. These NMR signals have previously been shown to reveal differences between cancer cells with various biological characteristics such as metastatic capacity and drug sensitivity. The proteolipid contains cholesterol, phospholipid, triglyceride, glycolipids, ether-linked lipids, and an apoprotein of unusual electrophoretic mobility. We have yet to confirm the presence of the mRNA reported by others. NMR spectroscopy could be used as a rapid method of identifying the presence of this proteolipid complex in human serum and aiding the diagnosis of malignant disease.

【 授权许可】

Unknown