Homology with hemopexin suggests a possible scavenging function for S‐protein/vitronectin

FEBS Letters

Stanley, K.K.¹ 

[1] European Molecular Biology Laboratory, Postfach 10.2209, Meyerhofstrasse 1, 6900 Heidelberg, FRG

关键词: S-protein;    Vitronectin;    Serum-spreading factor;    Hemopexin;    Sequence homology;    Structural homology;   

DOI  :  10.1016/0014-5793(86)80489-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

S-protein is an abundant plasma protein which has recently been shown to be identical to vitronectin and serum spreading factor [(1985) EMBO J. 4, 3153-3157]. It therefore has multiple binding sites for terminal complement complexes, thrombin-antithrombin III, heparin, and a specific cell receptor. In this report a structural and sequence homology with hemopexin is described which suggests that the principle function of S-protein could be as a scavenging molecule, clearing spent complement and coagulation complexes from the circulation

【 授权许可】

Unknown