Cytochrome P‐450‐dependent H2O2 production demonstrated in vivo

FEBS Letters

Premereur, Noël¹  Roels, Frank¹  Van den Branden, Christiane¹ 

[1] Laboratorium voor Menselijke Anatomie, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussel, Belgium

关键词: Cytochrome P-450;    H2O2 production;    Aminopyrine;    Phenobarbital;    Allylisopropylacetamide;   

DOI  :  10.1016/0014-5793(86)81215-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

By administration of allylisopropylacetamide, an inhibitor of cytochrome P-450, we demonstrated that cytochrome P-450 is involved in the production of H₂O₂ during aminopyrine metabolism and phenobarbital induction in both the unanaesthetized guinea pig and rat. In the guinea pig we also found evidence for the existence of a basal cytochrome P-450-dependent H₂O₂ production, i.e. in the absence of exogenous substrate. Catalase participates in the decomposition of H₂O₂ produced in the endoplasmic reticulum where cytochrome P-450 is localized.

【 授权许可】

Unknown