Fine tuning of ribosomal accuracy

FEBS Letters

Ninio, Jacques¹ 

[1] Institut Jacques Monod, Tow 43, 2 Place Jussieu, 75251 Paris Cedex 05, France

关键词: Translational accuracy;    Stringent control;    tRNA imbalance;    Mnemonic enzyme;   

DOI  :  10.1016/0014-5793(86)80202-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

If the rate constant for peptide bond formation were high just after an amino acid incorporation and occasionally switched to a lower value afterwards, then the ribosome could compensate for tRNA imbalance specifically at hungry codons. A rigorous analysis of the scheme proves its effectiveness. For instance, a 10-fold reduction in cognate tRNA concentration may increase the error rate by only a factor of two.

【 授权许可】

Unknown