Structure of the rat pro‐opiomelanocortin (POMC) gene

FEBS Letters

Charron, Jean¹  Chamberland, Michel¹  Jeannotte, Lucie¹  Nemer, Mona¹  Drouin, Jacques¹ 

[1] Laboratoire de Biologie Moléculaire des Eucaryotes, Institut de recherches cliniques de Montréal, 110 ouest. Avenue des Pins, Montréal, Québec H2W 1R7, Canada

关键词: Pro-opiomelanocortin;    DNA sequence;    Gene structure;   

DOI  :  10.1016/0014-5793(85)80078-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The gene encoding pro-opiomelanocortin (POMC) presents unique regulatory features. In particular, glucocorticoids inhibit transcription of the POMC gene in the anterior pituitary, but not in the intermediate pituitary. In order to study the mechanism leading to transcriptional inhibition of POMC by glucocorticoid and the interaction of the glucocorticoid receptor complex with specific DNA sequences along the POMC gene, we have cloned the rat POMC gene and determined its structure. The gene is composed of three exons and appears to be present at a single copy per haploid genome. Besides the usual regulatory signals like ‘TATA’ and ‘CCAAT’ boxes, the upstream region contains sequences homologous to known enhancer sequences and to the glucocorticoid receptor binding site observed in glucocorticoid-responsive genes.

【 授权许可】

Unknown