Specific inhibition of mitochondrial protein synthesis influences the amount of complex I in mitochondria of rat liver and Neurospora crassa directly

FEBS Letters

van den Bogert, C.¹  de Vries, H.¹  Holtrop, M.¹  Kroon, A.M.¹ 

[1] Laboratory of Physiological Chemistry, State University Medical School, Bloemsingel 10, 9712 KZ Groningen, The Netherlands

关键词: Protein synthesis inhibition NADH dehydrogenase;    Complex I;    Mitochondria;    (rat liver;    Neurospora crassa);   

DOI  :  10.1016/0014-5793(85)80112-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Specific inhibition of mitochondrial protein synthesis reduces the oxidation rate of NADH-linked substrates in rat liver as well as in Neurospora crassa mitochondria. The present study shows that this is due to the fact that inhibition of mitochondrial protein synthesis leads to a decrease of the concentration of active complex I. Therefore, these results demonstrate that at least one of the genes for the subunits of complex I is localized on mitochondrial DNA.

【 授权许可】

Unknown