Channeling of ammonia from glutaminase to carbamoyl‐phosphate synthetase in liver mitochondria

FEBS Letters

Meijer, Alfred J.¹ 

[1] Laboratory of Biochemistry, University of Amsterdam, PO Box 20151, Amsterdam, The Netherlands

关键词: Carbamoyl-phosphate synthetase;    Glutaminase;    Rat liver mitochondria;    Ammonia;    Channeling;    Citrulline;   

DOI  :  10.1016/0014-5793(85)80018-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In isolated rat-liver mitochondria the rate of citrulline synthesis from glutamine does not respond to changes in the ammonia concentration in the extramitochondrial fluid. This suggest that ammonia, produced in the mitochondria via glutaminase, is directly channeled to carbamoyl-phosphate synthetase.

【 授权许可】

Unknown