The 25 kDa protein kinase inhibitor present in liver cell is absent in fast growing HTC cells and is induced in sodium butyrate treated cells

FEBS Letters

Tichonicky, Lydie¹  Delpech, Marc¹  Lévy-Favatier, Florence¹  Kruh, Jacques¹ 

[1] Faculté de Médecine Cochin-Port-royal, Institute De Pathologie Moléculaire, Unité Associée CNRS, 24, rue du Fg Saint-Jacques, 75014 Paris, France

关键词: Protein kinase;    Enzyme inhibitor;    Cell growth regulation;    Sodium butyrate;    Hepatoma cell;    HMG proteins;    high mobility group proteins;    HTC cells;    hepatoma tissue cultured cells;   

DOI  :  10.1016/0014-5793(85)80447-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have recently characterized a cAMP independent protein kinase inhibitor in rat liver. This inhibitor is absent or inactive in fast growing HTC cells and is induced according to exponential kinetics by sodium butyrate, a compound which arrests cell growth at the G₁ phase of the cell cycle. It is suggested that the inhibitor could be involved in cell growth regulation.

【 授权许可】

Unknown