Poly ADP‐ribosylation ‐ A cellular emergency reaction?

FEBS Letters

Wintersberger, Erhard¹  Wintersberger, Ulrike² 

[1] Institute of Molecular Biology, University of Vienna, A-1090 Vienna, Austria;Institute for Tumor Biology/Cancer Research, University of Vienna, A-1090 Vienna, Austria

关键词: Poly ADP-ribose;    DNA repair;    NAD;    Nucleotide pool;    DNA replication;    Cellular stress;   

DOI  :  10.1016/0014-5793(85)80369-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We propose that the activation of poly(ADP-ribose) synthetase by DNA damage serves to decrease rapidly and transiently the cellular level of NAD (by production therefrom of poly ADP-ribose). The result is a slow-down of energy-requiring reactions, in particular of replicative DNA synthesis giving cells more time to repair the damage. We do not attribute any specific role to poly ADP-ribosylated proteins in this reaction beyond their action as acceptors for poly ADP-ribose

【 授权许可】

Unknown