Chemiosmotic coupling in cytochrome oxidase

FEBS Letters

Baum, Harold²  West, Ian C.¹  John Moody, A.¹  Mitchell, Roy¹  Mitchell, Peter¹  Wrigglesworth, John M.² 

[1] Glynn Research Institute, Bodmin, Cornwall PL30 40 AU, University of London, Manresa Road, London SW3 6XL, England;Department of Biochemistry, Chelsea College, University of London, Manresa Road, London SW3 6XL, England

关键词: Cytochrome oxidase;    Protonmotive O loop;    Protonmotive O cycle;    Vectorial ligand conduction;    Osmochemistry;    Catalytic mechanism;   

DOI  :  10.1016/0014-5793(85)80863-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using the principle of specific vectorial ligand conduction, we outline directly coupled protonmotive O loop and O cycle mechanisms of cytochrome oxidase action that are analogous to protonmotive Q loop and Q cycle mechanisms of QH₂ dehydrogenase action. We discuss these directly coupled mechanisms in the light of available experimental knowledge, and suggest that they may stimulate useful new research initiatives designed to elucidate the osmochemistry of protonmotive oxygen reduction in cytochrome oxidase.

【 授权许可】

Unknown