Protein thiols in normal and neoplastic human uterine cervix

FEBS Letters

Bajardi, F.⁸  Rojanapo, W.⁶  Nöhammer, G.¹  Benedetto, C.⁴  Dianzani, M.U.²  Schauenstein, E.¹  Bussolati, G.³  Slater, T.F.⁵  Ghiringhello, B.⁷  Cianfano, S.⁴ 

[1] Institute of Biochemistry, Karl-Franzens University, Graz, Austria;Institute of General Pathology, Corso Raffaello 30, Italy;Institute of Anatamo-Pathology, Via Santena 7, Italy;Institute of Gynaecology and Obstetrics, Chair A, Via Ventimiglia 3, Italy;Department of Biochemistry, Brunel University, Uxbridge, UB8 3PH, England;National Cancer Institute, Bangkok, Thailand;Pathology Department, Sont'Anna Hospital for Obstetrics and Gynaecology, Turin, Italy,;Cytologisches Laboratorium des Landeskrankenhauses, Graz, Austria

关键词: Protein-thiol;    Cervix;    Cancer;    Microspectrophotometry;    Epithelium;    Stroma;    Field-effect;   

DOI  :  10.1016/0014-5793(85)81256-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein-thiol groups that react with dihydroxydinaphthyl disulphide during a 7 h incubation (so-called reactive protein thiols, PSH_r) have been quantitatively measured on sections of human uterine cervix by microcytospectrophotometry. Measurements were made on areas (1 μm²) of epithelium and adjoining stroma in samples of normal cervix, and in samples obtained from patients with dysplasia, carcinoma-in-situ and invasive cancer. The ratio of PSH_r in epithelium to stroma is substantially reduced in the pathological conditions compared with normal and in apparently normal adjacent areas. Such changes in PSH_r are discussed in relation to the redox balance of the tissue, and free radical disturbances previously described.

【 授权许可】

Unknown