Tumour‐host metabolic interaction and cachexia

FEBS Letters

Lazo, Pedro A.¹ 

[1] Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA

关键词: Amino acid;    Cancer;    Cachexia;    Metabolism;    Growth;   

DOI  :  10.1016/0014-5793(85)81239-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cachexia is a terminal metabolic problem observed in a wide variety of tumours. In this article I propose that the syndrome is a direct consequence of the common feature to all malignant tumours: growth. I suggest that the requirement for essential amino acids can be used as the unifying principle that links the tumour to the two main components of cachexia: muscle wastage and anorexia. This underlying factor is usually clouded by the overlapping of individual tumour characteristics.

【 授权许可】

Unknown