Role of LncRNAs in regulating cancer amino acid metabolism

Cancer Cell International

Xiao-Bin Lv¹  Feifei Zhang¹  Yiping Liang¹  Zhiping Zhang²  Renfeng Liu³  Zhengzai Dai³  Bo Yu³  Yuhong Guo³  Duo Zeng³  Bin Lv³ 

[1]Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, 330008, Nanchang, Jiangxi, People’s Republic of China

[2]Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, 330008, Nanchang, Jiangxi, People’s Republic of China

[3]Department of Orthopedics, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, 330008, Nanchang, Jiangxi, People’s Republic of China

[4]Nanchang Key Laboratory of Orthopaedics, The Third Affiliated Hospital of Nanchang University, Nanchang, China

[5]Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, 330008, Nanchang, Jiangxi, People’s Republic of China

[6]Department of Orthopedics, The Third Affiliated Hospital of Nanchang University, Northern 128 Xiangshan Road, 330008, Nanchang, Jiangxi, People’s Republic of China

[7]Nanchang Key Laboratory of Orthopaedics, The Third Affiliated Hospital of Nanchang University, Nanchang, China

[8]Medical Department of Graduate School, Nanchang University, 330006, Nanchang, Jiangxi, China

关键词: lncRNA;    Metabolism;    Amino acid;    Glutamine;    Cancer;   

DOI  :  10.1186/s12935-021-01926-8

来源: Springer

【 摘 要 】

The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished metabolic characteristics called metabolic reprogramming, which has been considered as a sign of cancer occurrence. With the deepening of tumor research in recent years, people gradually found that amino acid metabolism played crucial roles in cancer progression. Long non-coding RNAs (lncRNAs), which are implicated in many important biological processes, were firstly discovered dysregulating in cancer tissues and participating in extensive regulation of tumorigenesis. This review focuses on the reprogramming of amino acid metabolism in cancers and how lncRNAs participate in the regulatory network by interacting with other macromolecular substances. Understanding the functions of lncRNA in amino acid reprogramming in tumors might provide a new vision on the mechanisms of tumorigenesis and the development of new approaches for cancer therapy.

【 授权许可】

CC BY