FEBS Letters | |
Cyclic AMP and c‐myc gene expression in PY815 mouse mastocytoma cells | |
De Feyter, R.1  Ralph, R.K.1  Le Gros, J.1  | |
[1] Department of Cell Biology, University of Auckland, Auckland, New Zealand | |
关键词: Cyclic AMP; c-myc gene; Gene expression; PY815 mouse mastocytoma cell; | |
DOI : 10.1016/0014-5793(85)81329-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The possibility was examined that inhibition of growth of PY815 mouse mastocytoma cells by N 6,O 2'-dibutyryladenosine 3',5'-cyclic monophosphate (DB cyclic AMP) results from inhibition of c-myc gene expression. Temporary increases in c-myc RNA which occurred soon after DB cyclic AMP treatment and upon removal of the drug were not consistent with direct inhibition of c-myc gene expression by DB cyclic AMP. The increases in c-myc RNA coincided with the passage through, or accumulation of cells in late G1 - early S phase. It is proposed that cyclic AMP may stimulate c-myc gene expression which normally occurs only in late G1 - early S phase in PY815 cells and that cyclic AMP prevents c-myc expression in cells at other phases of the cell cycle by inhibiting their progression past a cyclic AMP-sensitive restriction point in early G1 phase.
【 授权许可】
Unknown
【 预 览 】
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