Superoxide generation by either 1‐oleoyl‐2‐acetylglycerol or A23187 in human neutrophils is enhanced by indomethacin

FEBS Letters

Dale, M.Maureen¹  Penfield, Adrienne¹ 

[1] Department of Pharmacology, University College London, Gower Street, London WCIE6BT, England

关键词: Neutrophil;    Superoxide;    Phorbol ester;    Indomethacin;    Calcium;    OAG;    1-oleoyl-2-acetylglycerol;    DAG;    diacylglycerol;    PMA;    phorbol myristate acetate;    PI;    phosphatidylinositol;   

DOI  :  10.1016/0014-5793(85)80772-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Indomethacin at a concentration (1O⁻⁴ M) which depressed the effect on O₂ ⁻ generation by fMet-Leu-Phe, markedly enhanced O₂ ⁻, generation by both 1-oleoyl-2-acetylglycerol and the calcium ionophore, A23187. These results are explicable in terms of the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil.

【 授权许可】

Unknown