Bradykinin‐induced transient accumulation of inositol trisphosphate in neuron‐like cell line NG 108‐15 cells

FEBS Letters

Hattori, Hiroaki¹  Yano, Koh¹  Nozawa, Yoshinori¹  Higashida, Haruhiro² 

[1] Department of Biochemistry, Gifu University School of Medicine, Tsukasamachi-40, Gifu 500,Japan;Department of Pharmacology, Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa 920, Japan

关键词: Neuroblastoma × glioma;    Bradykinin;    Inositol trisphosphate;    Phosphodiesterase;    IP3;    inositol trisphosphate;    (1;    4;    5)IP3;    inositol 1;    4;    5-trisphosphate;    IP2;    inositol bisphosphate;    IP;    inositol monophosphate;    PIP2;    phosphatidylinositol 4;    5-bisphosphate;   

DOI  :  10.1016/0014-5793(85)80301-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Studies were undertaken to further elucidate the mechanism(s) by which bradykinin-dependent phosphoinositide metabolism takes place in neuroblastoma × glioma hybrid NG108-15 cells [(1984) J. Biol. Chem. 259, 10201–10207] using [³H]inositol-labelled cells. Bradykinin produced net increases in the level of [³H]inositol phosphates, especially of [₃H]inositol trisphosphate which is formed transiently and most rapidly. The results indicate that bradykinin activates a phosphodiesterase to break down phosphatidylinositol 4,5-bisphosphate, generating two recently recognized intracellular messengers, 1,2-diacylglycerol and inositol trisphosphate.

【 授权许可】

Unknown