Gene expression in the polycistronic operons of Escherichia coli heat‐labile toxin and cholera toxin: a new model of translational control

FEBS Letters

Mori, Nozomu¹  Wada, Akiyoshi²  Suyama, Akira²  Yokota, Takeshi³  Yamamoto, Tatsuo³ 

[1] Department of Biochemistry, School of Pharmaceutical Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan;Department of Physics, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan;Department of Bacteriology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan

关键词: Escherichia coli heat-labile toxin;    Cholera toxin;    Polycistronic operon;    mRNA secondary structure Translational control;   

DOI  :  10.1016/0014-5793(85)80296-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new model is proposed based on the suggestion that stable local secondary structures of mRNA interfere with ribosome movement on mRNA and consequently reduce the translation rate. This model accounts for a different level of translation for each cistron in the polycistronic mRNA of Escherichia coli heat-labile toxin (LT) and cholera toxin. We also conclude that the mRNA secondary structures have been conserved during the evolution of the toxin genes for its functional importance.

【 授权许可】

Unknown