Prostaglandins E1 and E2 enhance the stimulation of superoxide release by 1‐oleoyl‐2‐acetylglycerol from human neutrophils

FEBS Letters

Dale, M.Maureen¹  Penfield, Adrienne¹ 

[1] Department of Pharmacology, University College London, Gower Street, London WC1E6BT, England

关键词: Neutrophil;    Phorbol ester;    Protein kinase C;    Prostaglandin E;    fMet-Leu-Phe;    Phosphatidylinositol;    OAG;    1-oleoyl-2-acetylglycerol;    DAG;    diacylglycerol;    PMA;    phorbol myristate acetate;    PGE1;    prostaglandin E1;   

DOI  :  10.1016/0014-5793(85)80287-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Superoxide release from human neutrophils was stimulated either by receptor activation (using fMet-Leu-Phe) or by activating, independently, each of the two pathways considered to be involved in signal transduction-calcium mobilization (using the ionophore, A23187) and protein kinase C activation (using phorbol myristate acetate or 1-oleoyl-2-acetylglycerol). Prostaglandin E₁ (3 × 10⁻⁵ M) decreased fMet-Leu-Phe-stimulated superoxide release, had no effect on superoxide release stimulated by A23187, or by phorbol myristate acetate, and markedly enhanced the superoxide release stimulated by 1-oleoyl-2-acetylglycerol. Similar enhancement was obtained with prostaglandin E₂.

【 授权许可】

Unknown