A role for Ca2+ in the effect of very low frequency electromagnetic field on the blastogenesis of human lymphocytes

FEBS Letters

Alesse, E.¹  Reale, M.¹  Angeletti, P.U.¹  Conti, P.¹  Fieschi, C.¹  Gigante, G.E.¹  Cifone, M.G.¹ 

[1] Dipartimento di Scienze Biomediche dell'Università dell'Aquila, Collemaggio-67100 L'Aquila, Italy

关键词: Ca2+ flux;    Electromagnetic field;    Lymphocyte blastogenesis;    Phytohemagglutinin;    Phorbol-myristate-acetate;    Verapamil;    ELF;    very low frequency elec-tromagnetic field;    PHA;    phytohemagglutinin;    PMA;    phorbol-myristate-acetate;    CRPMI;    complete medium RPMI 1640;   

DOI  :  10.1016/0014-5793(85)81107-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The DNA synthesis of lymphocytes triggered by phytohemagglutinin or phorbol-myristate-acetate is strongly reduced by the externally applied electromagnetic field (ELF). Ca²⁺ uptake by stimulated lymphocytes is also reduced by ELF. The effect appears to be synergistic with that of the well-known calcium blocker agent, verapamil.

【 授权许可】

Unknown