Retarded decline in poly‐ADPR content and poly‐ADPR synthetase activity in chicken dystrophic muscle

FEBS Letters

Masaki, Tomoh²  Yoshikawa, Akira¹ 

[1] Research division, Saitama Red Cross Blood Center, 903, Kamiochiai, Yono-shi, Saitama-kenJapan 338;Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305, Japan

关键词: Poly-ADPR;    Muscular dystrophy;    Muscle development;    ADPR;    adenosine diphosphate ribose;    PR-AMP;    2'-(5''-phosphoribosyl)-5'-AMP;   

DOI  :  10.1016/0014-5793(85)80218-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activity of poly-ADPR synthetase declines just after hatching in normal chick muscle nuclei. However, in dystrophic chick muscle nuclei it decreases 5 weeks after hatching, A delayed decrease in the amount of poly-ADPR is also observed in dystrophic chick muscle nuclei. These observations suggest that dystrophic muscle follows an abnormal developmental program.

【 授权许可】

Unknown