Persistent activity modification of phosphatidate phosphohydrolase and fatty acyl‐CoA synthetase on incubation of adipocytes with the tumour promoter 12‐O‐tetradecanoylphorbol 13‐acetate

FEBS Letters

Saggerson, E.David¹  Hall, Michael¹  Taylor, Stephen J.¹ 

[1] Department of Biochemistry University College London, Gower Street, London WC1E 6BT, England

关键词: Adipocyte;    Phorbol ester;    Phosphatidate phosphohydrolase;    Fatty acyl-CoA synthetase;    Lipolysis;   

DOI  :  10.1016/0014-5793(85)80549-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Incubation of rat adipocytes with the phorbol ester TPA caused a dose-dependent, persistent increase in phosphatidate phosphohydrolase activity and decrease in fatty acyl-CoA synthetase activity. Half-maximal effects were obtained with 1–2 × 10⁻¹⁰ M TPA. TPA did not alter basal or noradrenaline-stimulated lipolysis. It is suggested that these two enzymes might be modified by protein kinase C.

【 授权许可】

Unknown