期刊论文详细信息
FEBS Letters | |
Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes | |
Ollmann, Marika1  Galla, Hans-Joachim1  | |
[1] Dept. Biochemistry, Tech. Hochschule Darmstadt, Petersenstr. 22, D-6100 Darmstadt, FRG | |
关键词: Membrane fluidity; Ganglioside; Phase separation; Hydrophilic interaction; ESR; | |
DOI : 10.1016/0014-5793(85)80214-3 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The effect of oligosaccharide carrying lipids on membrane fluidity has been investigated. Gangliosides GM1 and GQ1 were reconstituted into phosphatidylcholine bilayer membranes at low concentrations ( < 5 mol%). A strong fluidizing effect was observed leading to a suppression of the phase transition temperature. This was most pronounced with highly sialylated gangliosides. Ca2+ reverses the effect due to phase separation phenomena. We assume a hydrophilic lipid-lipid interaction in accordance with previously studied glycoprotein-lipid interactions.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020286237ZK.pdf | 340KB | download |