Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes

FEBS Letters

Ollmann, Marika¹  Galla, Hans-Joachim¹ 

[1] Dept. Biochemistry, Tech. Hochschule Darmstadt, Petersenstr. 22, D-6100 Darmstadt, FRG

关键词: Membrane fluidity;    Ganglioside;    Phase separation;    Hydrophilic interaction;    ESR;   

DOI  :  10.1016/0014-5793(85)80214-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of oligosaccharide carrying lipids on membrane fluidity has been investigated. Gangliosides GM1 and GQ1 were reconstituted into phosphatidylcholine bilayer membranes at low concentrations ( < 5 mol%). A strong fluidizing effect was observed leading to a suppression of the phase transition temperature. This was most pronounced with highly sialylated gangliosides. Ca²⁺ reverses the effect due to phase separation phenomena. We assume a hydrophilic lipid-lipid interaction in accordance with previously studied glycoprotein-lipid interactions.

【 授权许可】

Unknown